Defense Technological Innovation describes the emerging paradigm for innovation at the US Department of Defense, and the consequent impacts on its stakeholders. Leveraging a combination of prior research, archival data, first-person observations and interviews, the authors identify practices and themes characterizing the key trends in defense innovation, describe current organizational approaches and practices, and develop a theoretical framework that elucidates the competencies required to underwrite defense innovation objectives. The findings therein are relevant to any large, technology-driven organization contending with the implications of rapid change in the high-tech landscape.